Est. MMXXIVIssue №135Vol. II
London - LisbonThu 29 Oct 2026

Read Before Monday

A weekly dispatch by Vitor Domingos · With links, on Sunday, nothing urgent
№ 135 / Weekly
Issue 47
Sun 9 Feb
Sunday Dispatch · № 47 · 9 Feb 2025

Another interesting week! Lets review recent advancements across diverse fields, which underscore the transformative potential and inherent challenges of integrating advanced technologies into society. Starting in healthcare, FIBRESOLVE’s FDA authorisation for AI-driven diagnostics exemplifies the critical interplay between interdisciplinary expertise and the need for careful oversight to mitigate concerns over opacity and data privacy, while addressing resistance within the radiology community. In parallel, efforts chronicled by Dr. Shailee Jain in UCSF Magazine reveal ambitious progress toward a “silicon brain”- an artificial neural network that, by synthesising diverse data from fMRI and single neuron recordings, aims to decode thoughts, restore speech, and create personalised brain models for revolutionary neurological treatments. Meanwhile, a Reuters Institute study exposes a complex global landscape in which the anticipated impacts of Generative AI on news media are met with low public trust, particularly in the UK, highlighting the broader societal caution toward these transformative tools. This blend of optimism and scepticism is further echoed in Virginia Postrel’s reflections on mid-20th-century futuristic visions that once promised a world of technological marvels but eventually gave way to concerns over pollution and societal limitations, and in the innovative concept of microarchitectural weird machines presented in Communications of the ACM, where computing through hardware side effects challenges conventional detection methods and opens new avenues for obfuscation.

In this issue
5 pieces

The integration of AI into medical diagnostics, exemplified by FIBRESOLVE's FDA authorisation , signifies a pivotal advancement in healthcare technology.

The integration of AI into medical diagnostics, exemplified by FIBRESOLVE's FDA authorisation , signifies a pivotal advancement in healthcare technology.

This development underscores the importance of interdisciplinary expertise in bridging the gap between medicine and technology. However, the persistence of concerns regarding AI's opacity and the necessity for human oversight highlights the need for strategic implementation. Addressing resistance within the radiology community and ensuring data privacy are critical factors for successful adoption. As AI continues to evolve, its role in enhancing patient care and clinical efficiency will depend on thoughtful integration and ongoing evaluation.

My take

It's fascinating to see AI/GenAI making waves into healthcare, especially with tools like these leading the charge. However, the term "black box" keeps popping up in my mind, reminding me of those mystery novels where the detective knows the outcome but not the 'how' or 'why.' Which for this particular case, in medicine, not knowing the 'how' can be a tough pill to swallow - see what I did here? :) And let's not forget the human element; even the smartest of the AI's can't replace the nuanced judgment of a radiologist. It's always good to remember that, as we embrace these innovations, balancing enthusiasm with caution seems like the best prescription.

In a Winter 2025 article from UCSF Magazine, Dr. Shailee Jain discusses efforts to create a "silicon brain" - an artificial neural network designed to replicate human brain activity.

In a Winter 2025 article from UCSF Magazine, Dr. Shailee Jain discusses efforts to create a "silicon brain" - an artificial neural network designed to replicate human brain activity.

This technology aims to decode thoughts, restore speech, and develop personalised brain models. By integrating diverse data sources, including fMRI and single neuron recordings, with advanced AI, researchers hope to revolutionise treatments for neurological disorders and enhance brain-computer interfaces.

My take

The ambition to construct a "silicon brain"; an artificial neural network mirroring human cognition, is undeniably captivating and I'm all in for it! The potential to decode thoughts or restore speech could revolutionize medicine and our understanding of the mind. However, lets not forget that it's crucial to recognize that these silicon constructs, no matter how advanced they look and sound, they lack consciousness, intent, or genuine understanding. It's just a system processing data and executing algorithms, math, amplifying human-designed functions without possessing awareness or conscience. I think the real challenge lies not in fearing these creations as rivals but in ensuring their responsible development and deployment. If we focus on transparent and accountable practices, we can really use these tools to enhance our human potential, viewing them as extensions of our capabilities rather than competitors for consciousness. Embracing this perspective could let us explore applications in education, medicine, and beyond, ensuring that technology serves as a servant to humanity, not a threat. Think about that...

A recent study by the Reuters Institute for the Study of Journalism examined public perceptions of Generative AI in news across six countries

A recent study by the Reuters Institute for the Study of Journalism examined public perceptions of Generative AI in news across six countries

. The findings reveal a complex landscape of awareness, usage, and trust. While a majority anticipate significant impacts of generative AI on various sectors, including news media, trust in institutions to use AI responsibly remains low. Notably, only 12% of respondents in the UK trust news media to use generative AI responsibly.

My take

Integrating generative GenAI into newsrooms offers significant opportunities for efficiency and innovation, for sure, however, it also raises concerns about trust and responsible use. The public's skepticism isn't about the technology itself, I think, but about how it's used. News orgs must prioritise transparency and responsibility in their GenAI applications to bridge this trust gap. After all, GenAI should enhance journalism, not undermine its integrity. Despite widespread awareness of tools like ChatGPT, actual application for news consumption remains minimal, with a mere 5% using GenAI to access the latest news - and maybe that will change with scheduled tasks from OpenAI and search. But, concerns about the accuracy and reliability of GenAI generated content will persist, especially in critical areas like politics and international affairs. This raises questions about the potential for misinformation and the erosion of journalistic integrity. Bottom line, it's essential to recognise that GenAI is not a sentient entity capable of intent. It functions as a tool, amplifying the directives and biases of its human creators - as always! The real challenge lies in how we choose to implement and oversee this technology. Rather than viewing GenAI as an existential threat to journalism, the focus should be on establishing responsible frameworks, ensuring transparency, and maintaining human oversight. I sense you can fell where I'm going to with these topics now :)

In her article " The World of Tomorrow ," Virginia Postrel reflects on the mid-20th century's optimistic visions of the future

In her article " The World of Tomorrow ," Virginia Postrel reflects on the mid-20th century's optimistic visions of the future

, epitomised by events like the 1939 New York World's Fair and Disneyland's Tomorrowland. These venues showcased a future brimming with technological marvels and societal advancements, instilling a sense of hope and excitement. However, as time progressed, this enthusiasm waned, giving way to concerns about pollution, overcrowding, and the limitations of progress. Postrel delves into the cultural shift that transformed the future from a glamorous ideal to a source of apprehension, exploring the factors that led to this change in perception.

My take

Lets reflect on the mid-20th century's starry-eyed visions of the future, it's clear that our collective imagination was once captivated by the promise of flying cars, utopian cities, and boundless technological wonders. The 1939 New York World's Fair and Disneyland's Tomorrowland weren't just attractions; they were embodiments of an era's unbridled optimism. Fast forward to today, and that shimmering image of "The World of Tomorrow" has been clouded by environmental concerns, social challenges, and a realisation that progress isn't always linear. It's a clear reminder that while it's essential to dream big, we must also remain grounded, ensuring that our pursuit of advancement doesn't overshadow the very values and realities that define our humanity.

n the article "C omputing with Time: Microarchitectural Weird Machines ," published in Communications of the ACM in November 2024

n the article "C omputing with Time: Microarchitectural Weird Machines ," published in Communications of the ACM in November 2024

I, authors Thomas S. Benjamin et al. introduce the concept of microarchitectural weird machines (μWMs). These are code constructions that perform computations through side effects and conflicts between microarchitectural components like branch predictors and caches. The outcomes of these computations are observed as timing variations during instruction execution. The authors demonstrate how μWMs can serve as potent obfuscation engines, enabling computations that remain undetectable by conventional anti-obfuscation tools, including emulators, debuggers, and both static and dynamic analysis techniques.

My take

This exploration of microarchitectural weird machines (μWMs) opens for me, a fascinating, yet concerning chapter in the realm of cybersecurity. The ingenuity of leveraging CPU microarchitectural side effects to perform covert computations showcases the depth of complexity inherent in modern processors. However, this also underscores a significant vulnerability: the very features designed to enhance performance can be repurposed to obfuscate malicious activities. This duality presents a formidable challenge for us, security professionals. As we continue to push the boundaries of computational efficiency and capability - hello DeepSeek - , it becomes important to anticipate and mitigate the unintended avenues these advancements may open for exploitation. This study serves as a clear reminder that in the intricate dance between innovation and security, vigilance must remain paramount.

The Premise
What you need to read before your busy Monday, published every Sunday

Read Before Monday is a weekly newsletter from Vitor Domingos - with a handful of articles, essays and oddities collected over the week, annotated with a short opinion, and sent before Monday morning.

No breaking news. No ten-thousand-word think pieces. No affiliate links. Just a small, curated and considered list of things worth sitting with.

VD
Vitor Domingos
Writing from London
Colophon
Type Archivo · Space Mono
Cadence Sun · 19:00 WET
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