Est. MMXXIVIssue №135Vol. II
London - LisbonWed 28 Oct 2026

Read Before Monday

A weekly dispatch by Vitor Domingos · With links, on Sunday, nothing urgent
№ 135 / Weekly
Issue 24
Sun 18 Aug
Sunday Dispatch · № 24 · 18 Aug 2024

It’s still August! A lot of you are on vacation, enjoying the sun, the beach and I’m here posting… But to those hanging around, this weeks edition is about how amazing it is to see passion and dedication can do and drive us, whether it’s restoring the first Air Force One, embracing the balance between liquid and illiquid career paths, or even using AI to revolutionise drug discovery. So, whether you’re fixing a relationship, navigating a career change, or working on a project, success often comes from blending tradition with innovation – right?. Then, just like in gaming, where isometric projection holds nostalgic value, sometimes the old ways, mixed with new techniques, can lead to the best outcomes.

In this issue
5 pieces

Ken Shea's details its dedicated effort to restore the first-ever Air Force One, a Lockheed Constellation named "Columbine II."

Ken Shea's details its dedicated effort to restore the first-ever Air Force One, a Lockheed Constellation named "Columbine II."

After years of neglect, Shea found the plane in Arizona and has been working to preserve this significant piece of aviation history. The restoration is challenging due to its size, complexity, and the specialised knowledge required, but Shea's passion drives the project. The story underscores the importance of preserving historical artefacts and the personal commitment needed to see such projects through.

My take

I always find interesting the extend people go to fix and repair stuff. This is one of its true examples! Columbine was the first aircraft to bear the Air Force One designation and it's amazing to see Shea's personal mission to restore it. I'm no military fan, don't get me wrong, but one thing is repairing and bringing back that old motorcycle, another is an entire plane - in particular, this historical artefact. Any project that has true passion in it, will always succeed, but this might be one of those really complex due to its high costs of restoration, in particular when you want to make it complaint with modern safety.

"Repair and Remain" reflects on the value of perseverance and commitment in both personal relationships and practical tasks.

"Repair and Remain" reflects on the value of perseverance and commitment in both personal relationships and practical tasks.

Kurt Armstrong advocates for the idea of fixing and maintaining what you have - whether it’s a house, marriage, or life - rather than seeking constant novelty or abandoning things when they become difficult. He emphasises that this approach, while simple, requires significant effort and resilience, countering a culture that often prioritises ease and newness over enduring and repairing.

My take

Just to keep on topic and because August is slow and the best time to repair stuff - and maybe you're inspired by now to restore some old stuff around the house ... But first how about fixing things? :) Like in relationships, repairing is better than replacing. We all have the consumerist mindset of constant novelty, we live in a tech world, I know, but this article highlights the difficulty but necessity of enduring hardships, it suggests tradition and repair over constant innovation and change - which it all applies to tech too.

The article "Liquid vs. Illiquid Careers" by Vaishnav Sunil explores the concept of career liquidity,

The article "Liquid vs. Illiquid Careers" by Vaishnav Sunil explores the concept of career liquidity,

comparing linear, easily understood career paths ("liquid") with non-linear, less conventional ones ("illiquid"). Liquid careers offer predictability and easier marketability, while illiquid careers, though riskier, can potentially yield higher returns and unique opportunities. Success in illiquid paths requires resilience, active management, and strong social capital, whereas liquid paths provide more stability and psychological comfort.

My take

this hit quite home for me :) I think frequent job changes often suggest a liquid career due to the ability to adapt, market oneself, and seize opportunities quickly - that's what I'be been doing throughout my career. But, over time, if these moves involve diverse roles or industries, your career might develop illiquid characteristics, requiring you to leverage unique experiences and niche skills, or even developed what you think you didn't had. For me was working for a communication agency, that was one of the best - out of the box - experiences that moved me to be an evangelist now. The key to success here lies in balancing the predictability and security of liquid careers with the higher potential rewards of an illiquid path. You must be strategic, ensuring that each move builds on the previous one, adding value and positioning them well for the future.

Pikuma explores the concept of isometric projection in video games , explaining how it differs from other forms of projection like perspective projection.

Pikuma explores the concept of isometric projection in video games , explaining how it differs from other forms of projection like perspective projection.

It discusses the mathematical principles behind isometric views, where objects are depicted without distortion regardless of distance, maintaining consistent proportions. This technique has been popular in classic games like "SimCity" and "Diablo" because it offers a clear, uniform view of the game world, enhancing gameplay and visual appeal without requiring complex 3D rendering.

My take

It's been a dense newsletter so far, right? Uff! So lets focus on games now :) I've always been a fan of SimCity and Diablo, which influenced me for decades. The unique 30 degree look creates a 3D alike experience, without being actually 3D. That's what games back then were, they would give you an illusion and you'll fill the rest in your head :) Whilst isometric projection is seen as nostalgic, some modern games prefer full 3D for more flexibility - which is ok, but for the nostalgic fans like me, there's nothing like this perspective.

ExoSwan explores the role of artificial intelligence (AI) in drug discovery , highlighting how AI is revolutionizing the pharmaceutical industry

ExoSwan explores the role of artificial intelligence (AI) in drug discovery , highlighting how AI is revolutionizing the pharmaceutical industry

by speeding up the discovery process, reducing costs, and improving the accuracy of identifying potential drug candidates. The piece discusses various AI techniques, such as machine learning and deep learning, and their applications in understanding complex biological data, predicting drug efficacy, and personalising treatments.

My take

This is quite interesting, to see how medicine and drugs are being helped by AI. There was another interesting article about Ozempic and the need for clinical data related to obesity. We can see now that AI significantly reduces the time needed for drug discovery, making the process faster than traditional methods. It also lowers the financial burden of bringing new drugs to market and, this is important, allows for the development of drugs tailored to individual genetic profiles. But its effectiveness relies heavily on the quality and quantity of data, which may not always be available. And of course, there are ethical issues regarding data privacy and the potential for AI to reinforce biases in drug development. It's a brand new world now :)

The Premise
What you need to read before your busy Monday, published every Sunday

Read Before Monday is a weekly newsletter from Vitor Domingos - with a handful of articles, essays and oddities collected over the week, annotated with a short opinion, and sent before Monday morning.

No breaking news. No ten-thousand-word think pieces. No affiliate links. Just a small, curated and considered list of things worth sitting with.

VD
Vitor Domingos
Writing from London
Colophon
Type Archivo · Space Mono
Cadence Sun · 19:00 WET
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